28 June 2000 Clinical experiences with fluorescence guided resection of malignant glioma
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Survival after surgery and radiotherapy of malignant glioma is closely linked to the completeness of tumor removal. Therefore methods are needed that permit intra-operative identification of tumor border lines. For tumor staining 5-ALA induced PPIX is used. The influence of fluorescence guided resection on the survival is analyzed. 66 patients received 20 mg/kg bodyweight 5-ALA per os 3 hours before anaesthesia. Fluorescence was visualized using a modified operating microscope. Fluorescing tissue was removed as complete as possible. 72 hours after surgery MIII —images were taken and residual enhancements quantified. Patients survival was analysed using the Kaplan-Meier method in correlation with Karnofsky-status, age, histology of tumor. These 66 patients were compared to 89 patients operated on between 1990 — 1992. Complete resection ofmalignant and fluorescing tumor was obtained in 62 % of patients. Compared to the historical group ofpatients survival using 5-ALA was significantly prolonged.
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Walter Stummer, Walter Stummer, Susanne Stocker, Susanne Stocker, Herbert G. Stepp, Herbert G. Stepp, Karl Bise, Karl Bise, Hanns-Juergen Reulen, Hanns-Juergen Reulen, Reinhold Baumgartner, Reinhold Baumgartner, "Clinical experiences with fluorescence guided resection of malignant glioma", Proc. SPIE 4166, Laser Florence '99: A Window on the Laser Medicine World, (28 June 2000); doi: 10.1117/12.389472; https://doi.org/10.1117/12.389472

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