11 October 2000 Imaging of lymph flow in single microvessels in vivo
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Proceedings Volume 4224, Biomedical Photonics and Optoelectronic Imaging; (2000) https://doi.org/10.1117/12.403938
Event: Optics and Optoelectronic Inspection and Control: Techniques, Applications, and Instruments, 2000, Beijing, China
Abstract
In this study parameters of lymph microcirculation are investigated. The microcirculation was studied on small intestine mesentery in norm and during Dimethyl sulfoxide (DMSO) application. The direct measurement of lymph flow velocity (parameter V) in individual microvessels was based on the technique of light intravital videomicroscopy. The first spectral moments of Doppler signal, characterizing the mean velocities of lymph flow in microvessels (parameter M1), were measured by speckle-interferometrical method. Simultaneously, diameters of lymph microvessels as well as parameters of phasic contractions and valve function of lymphatics were registered. The value of V was very changeable; the mean V was equal to 270+/- 24micrometers /s. The M1 was the varying characteristic of the lymph flow too. The temporal dynamic of M1 was reflected alternating- translation motion of lymph flow. DMSO application during 15 min caused the constriction in a majority of lymphatics and the phasic contractions. DMSO induced lymphostatis in 20% of cases. But the other microvessels responded to the rise of lymph flow velocity. These changes led to the stimulation of drainage function of lymph microcirculation function.
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Ekateryna I. Galanzha, Ekateryna I. Galanzha, Sergey S. Ulyanov, Sergey S. Ulyanov, Valery V. Tuchin, Valery V. Tuchin, Gregory E. Brill, Gregory E. Brill, Anastasiya V. Solov'eva, Anastasiya V. Solov'eva, } "Imaging of lymph flow in single microvessels in vivo", Proc. SPIE 4224, Biomedical Photonics and Optoelectronic Imaging, (11 October 2000); doi: 10.1117/12.403938; https://doi.org/10.1117/12.403938
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