Main directions of investigations and possible applications of laser systems generating radiation within 'eye safe' range are presented. The results of examinations of spectroscopic properties and generation parameters of new active media, i.e., Er3+ and Yb3+ doped glasses and Er3+, Cr4+, Ho3+, Tb3+, and Tm3+ ions doped crystal are given. Substantial optical and structural characteristics of new materials used for radiation conversion systems, including shift of generated wavelength to 'eye safe' range with application of molecular crystalline Raman shifter and OPO generators have been determined. We present also the results of investigations on spectroscopic properties and non-linear absorption effect in new absorbers used for the systems generating radiation at 1.5 micrometers such as YAG:V3+, U2+ doped difluoride alkaline earth metals and glasses, Er3+ doped crystals, and Co2+ ions doped media. Literature data was compared with the results obtained for investigations carried out at the Institute of Optoelectronics and relate to materials engineering, spectroscopy, structural analysis, and generation characteristics of various laser systems generating radiation within a spectral range of 1.5 divided by 2 micrometers .