4 May 2001 Photobleaching of endogenous fluorochroms in tissues in vivo during laser irradiation
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The photobleaching phenomenon has been previously first of all widely studied for exogenous photosensitizers applied in photodynamic therapy (PDT). The present paper deals with detailed investigation of photobleaching of endogenous fluorochroms in tissues in vivo during its laser irradiation at 532, 633 and 670 nm at different powers. The fluorescence decay curves during skin irradiation in vivo at these wavelengths have been obtained and analyzed. The similarity in bleaching behavior of endogenous fluorochroms and exogenous photosensitizers used in PDT gave us the reasons to imply the possible connection between native fluorochroms and low intensity laser therapy effects. The results obtained may be applied for tissue diagnostics and therapy control.
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Alexander A. Stratonnikov, Alexander A. Stratonnikov, Vladimir S. Polikarpov, Vladimir S. Polikarpov, Victor B. Loschenov, Victor B. Loschenov, } "Photobleaching of endogenous fluorochroms in tissues in vivo during laser irradiation", Proc. SPIE 4241, Saratov Fall Meeting 2000: Optical Technologies in Biophysics and Medicine II, (4 May 2001); doi: 10.1117/12.431555; https://doi.org/10.1117/12.431555

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