Combined photoultrasonic treatment of infected wounds

Vladimir P. Zharov; Yulian A. Menyaev; Konstantin L. Kalinin; Gregory N. Zmievskoy; Leonid Z. Velsher; Alexander A. Podkolzin; Mikhail L. Stakhanov; Yury Y. Gorchak; V. P. Sarantsev

doi:10.1117/12.427780

21 May 2001 Combined photoultrasonic treatment of infected wounds

Vladimir P. Zharov, Yulian A. Menyaev, Konstantin L. Kalinin, Gregory N. Zmievskoy, Leonid Z. Velsher, Alexander A. Podkolzin, Mikhail L. Stakhanov, Yury Y. Gorchak, V. P. Sarantsev

Author Affiliations +

Proceedings Volume 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI; (2001) https://doi.org/10.1117/12.427780
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

A new combined photoultrasonic (CPUS) technology for the treatment of infected wounds is suggested. The CPUS principal operation is based on the topical application of a photosensitizer followed by light irradiation in combination with low frequency ultrasonic (US) treatment of wounds. In CPUS, two methods - photodynamic (PDT) and ultrasonic therapies supplement each other beneficially and in conjunction provide a significant effect of deep suppurative inflammatory wounds treatment. The main advantages of the new technology are the combined application of an antibiotic solution and photodynamic therapy to destroy antibiotic- resistant microorganisms, an effective mixing of a photosensitizer in the wound, the US enhancement of photosensitizer impregnation into the membranes of bacteria, the US clearing of wound surface from necrotic products, an increased effective light dose exposure in the whole volume of the deep wound when the light does not penetrate totally inside the wound, an additional bactericidal effect under the US impact, and the combined effect of CPUS activation of the immune system.

Citation Download Citation

Vladimir P. Zharov, Yulian A. Menyaev, Konstantin L. Kalinin, Gregory N. Zmievskoy, Leonid Z. Velsher, Alexander A. Podkolzin, Mikhail L. Stakhanov, Yury Y. Gorchak, and V. P. Sarantsev "Combined photoultrasonic treatment of infected wounds", Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); https://doi.org/10.1117/12.427780

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available