Cooperative phenomena in two-pulse two-color laser photocoagulation of cutaneous blood vessels

John F. Black; Jennifer Kehlet Barton; George Frangineas Jr.; Herbert Pummer

doi:10.1117/12.427786

21 May 2001 Cooperative phenomena in two-pulse two-color laser photocoagulation of cutaneous blood vessels

John F. Black, Jennifer Kehlet Barton, George Frangineas Jr., Herbert Pummer

Proceedings Volume 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI; (2001) https://doi.org/10.1117/12.427786
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

A novel laser system has been developed to study the effects of multiple laser pulses of differing wavelengths on cutaneous blood vessels in vivo, using the hamster dorsal skin flap preparation. The system permits sequenced irradiation with well-defined intrapulse spacing at 532 nm, using a long pulse frequency doubled Nd:YAG laser, and at 1064 nm, using a long pulse Nd:YAG laser. Using this system, we have identified a parameter space where two pulses of different wavelengths act in a synergistic manner to effect permanent vessel damage at radiant exposures where the two pulses individually have little or no effect. Using a two- color pump-probe technique in vitro, we have identified a phenomenon we call green-light-induced infrared absorption (GLIIRA), where a pulse of green light causes photochemical and photothermal modifications to the chemical constituents of blood and results in enhanced infrared absorption. We identify a new chemical species, met-hemoglobin, not normally present in healthy human blood but formed during laser photocoagulation which we believe is implicated in the enhanced IR absorption.

Citation Download Citation

John F. Black, Jennifer Kehlet Barton, George Frangineas Jr., and Herbert Pummer "Cooperative phenomena in two-pulse two-color laser photocoagulation of cutaneous blood vessels", Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); https://doi.org/10.1117/12.427786

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available