9 April 2001 Fluence rate effects in human glioma spheroids: implications for photodynamic therapy of brain tumors
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Proceedings Volume 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X; (2001) https://doi.org/10.1117/12.424447
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States
Abstract
The effects of fluence rate are investigated in human glioma spheroids incubated in 5-aminolevulinic acid (ALA). It is shown that the response of glioma spheroids to ALA-mediated PDT depends strongly on the rate at which the light dose is delivered. At low doses, lower fluence rates are more effective. For example, at a dose of 50 JIcm2, near total spheroid kill is observed at fluence rates of as low as 1 0 mW/cm2. Below 1 0 mW/cm2, however, treatments are not as effective. The fluence rate effect is not as pronounced at higher doses where a favorable response is observed throughout the range of fluence rates investigated. The clinical implications ofthese findings are discussed.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Steen J. Madsen, Steen J. Madsen, Chung-Ho Sun, Chung-Ho Sun, Bruce J. Tromberg, Bruce J. Tromberg, Henry Hirschberg, Henry Hirschberg, } "Fluence rate effects in human glioma spheroids: implications for photodynamic therapy of brain tumors", Proc. SPIE 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, (9 April 2001); doi: 10.1117/12.424447; https://doi.org/10.1117/12.424447
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