Photodynamic therapy in thoracic oncology: a single institution experience

James D. Luketich M.D.; Hiran C. Fernando M.D.; Neil A. Christie M.D.; Virginia R. Litle; Peter F. Ferson; Percival O. Buenaventura

doi:10.1117/12.424453

9 April 2001 Photodynamic therapy in thoracic oncology: a single institution experience

James D. Luketich M.D., Hiran C. Fernando M.D., Neil A. Christie M.D., Virginia R. Litle, Peter F. Ferson, Percival O. Buenaventura

Author Affiliations +

Proceedings Volume 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X; (2001) https://doi.org/10.1117/12.424453
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

We have performed 800 photodynamic therapy (PDT) treatments in over 300 patients at the University of Pittsburgh since 1996. Over 150 patients have undergone PDT for palliation of dysphagia for esophageal cancer. Of the first 77 dysphagia improved in 90.8% with a mean dysphagia-free interval of 80 days. An expandable metal stent was required for extrinsic compression in 19 patients. We have treated 14 high-risk patients with early esophageal cancer or Barrett's high-grade dysplasia for curative intent. At a median follow-up of 12.8 months eight remain free of cancer. Over 100 patients have undergone PDT for lung cancer. Sixty-two patients received 77 courses for palliation. Thirty-five patients were treated for non-massive hemoptysis with resolution in 90%. Forty-four patients were treated for dyspnea with improvement in 59%. A subset of seven high-risk patients with early lung cancer were treated with curative intent. A complete response was seen in 7/10 lesions at a mean follow-up of 30 months. PDT offers good palliation for both advanced esophageal and lung cancer. The role of PDT for curative intent needs further investigation in protocol settings. In our preliminary experience we have treated a small number of non-surgical, high-risk patients with a reasonable success rate.

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James D. Luketich M.D., Hiran C. Fernando M.D., Neil A. Christie M.D., Virginia R. Litle, Peter F. Ferson, and Percival O. Buenaventura "Photodynamic therapy in thoracic oncology: a single institution experience", Proc. SPIE 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, (9 April 2001); https://doi.org/10.1117/12.424453

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