9 April 2001 Photodynamic therapy using Verteporfin and 630-nm laser light in canine esophagus
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Proceedings Volume 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X; (2001) https://doi.org/10.1117/12.424434
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States
Abstract
Objective: The goal ofthis study was to determine a relationship between light dose and the delay time between administration of Verteporfin and light to ablate canine esophageal mucosa. Materials and Methods: Verteporfin was administered IV (0.75 mg/lg). 630-nm light from KTP/Dye laser was delivered using a 9-cm diffuser inside a specially designed reflective 7-cm windowed balloon. Initially, animals were treated at doses of 160 J/cm, 180 J/cm, 200 J/cm, and 220 J/cm 2-3 hours after Verteporfin injection. Based on the acute response in these animals and the plasma Verteporfin clearance, other treatments were devised and tested at 60 J/cm (at 1 5 minutes), 80 J/cm (22 minutes), 100 J/cm (30 minutes), and 145 J/cm (60 minutes). Results: In initial animals, 200 J/cm at 2 hours induced acceptable mucosal ablation. Using this light dose and the plasma drug clearance, subsequent treatments were tested resulting in similar injuries using 60 3/cm (15 minutes), 80 3/cm (22 minutes), 100 3/cm (30 minutes), and 145 J/cm (60 minutes). Conclusions: A relationship was established relating the light dose and the delay time between administration oflight and Verteporfin for ablation ofnormal canine esophageal mucosa.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Masoud Panjehpour, Masoud Panjehpour, Robert C. DeNovo, Robert C. DeNovo, Mark G. Petersen, Mark G. Petersen, Bergein F. Overholt, Bergein F. Overholt, Barbara Kelly, Barbara Kelly, Robert D. Bower, Robert D. Bower, Valery Rubinchik, Valery Rubinchik, } "Photodynamic therapy using Verteporfin and 630-nm laser light in canine esophagus", Proc. SPIE 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, (9 April 2001); doi: 10.1117/12.424434; https://doi.org/10.1117/12.424434
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