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29 June 2001 Broadband absorption spectroscopy by combining frequency-domain and steady-state techniques
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Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434510
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States
Abstract
A technique for measuring broadband near-infrared absorption spectra of turbid media is presented using a combination of frequency-domain (FD) and steady-state (SS) reflectance methods. Most of the wavelength coverage is provided by a white-light SS measurement, while the FD data are acquired at a few selected wavelengths. Coefficients of absorption ((mu) a) and reduced scattering ((mu) s') derived from the FD data are used to intensity-calibrate the SS measurements and to estimate (mu) s' at all wavelengths in the spectral window of interest. After these steps are performed, (mu) a can be determined by comparing the SS reflectance values to the predictions of diffusion theory, wavelength by wavelength. We present an application of this method to breast tumor characterization. A case study of a fibroadenoma is shown, where different absorption spectra were found between the normal and the tumor sides.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Andrew J. Berger, Frederic Bevilacqua, Dorota B. Jakubowski, Albert E. Cerussi, John A. Butler, D. Hsiang, and Bruce J. Tromberg "Broadband absorption spectroscopy by combining frequency-domain and steady-state techniques", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434510
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