29 June 2001 Differential imaging in heterogeneous media: limitations of linearization assumptions in optical tomography
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Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434511
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States
Image reconstruction and data collection in optical tomography can be achieved in a number of different ways. This paper explores the limitations of using assumptions of linearity, particularly in the case where image data is acquired before and after a change in optical properties within an object with heterogeneous optical properties. The effects of using a 2 dimensional (2D) reconstruction scheme for changes in 3D measurements are also demonstrated. Problems are a direct result of the inherent non-linearity of optical tomographic image reconstruction. We show how these assumptions affect images of changes in absorption in the presence of a) heterogeneous background scatter, and b) heterogeneous background absorption using both simulations and time-resolved experimental data. Comparisons of results using non-linear and linear image reconstruction techniques are included throughout. The origin and dependence of the error are investigated. Methods to improve results by using estimates of background structure from baseline images are shown to improve quantitation and object localization in simple images. The potential significance of this error is discussed in relation to successful, reliable clinical imaging of the neonatal brain.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Elizabeth M. C. Hillman, Elizabeth M. C. Hillman, Hamid Dehghani, Hamid Dehghani, Jeremy C. Hebden, Jeremy C. Hebden, Simon Robert Arridge, Simon Robert Arridge, Martin Schweiger, Martin Schweiger, David T. Delpy, David T. Delpy, } "Differential imaging in heterogeneous media: limitations of linearization assumptions in optical tomography", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434511; https://doi.org/10.1117/12.434511

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