29 June 2001 Effect of multiple layers on diffuse optical tomography
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Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434478
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States
Abstract
In this work we investigate the effect of a layer on Diffuse Optical Tomography of tissue. Such layers could be tissue structures (such as the skin or a fat-layer) or layers formed by compression plates. Our analysis uses an analytical forward model that is based on the angular spectrum representation of the propagating photon density wave in a diffuse medium. The inversion employs a standard perturbation expansion based on the Rytov approximation that is uses appropriate volume segmentation and solved using the algebraic reconstruction technique. The results demonstrate that the effect of biologically relevant multi-layer schemes can lead to significant reconstruction errors both in terms of quantification and positional certainty. The work is focussed on geometries and optical properties typical to the human breast, however the results are general and can apply to other tissue as well.
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Vasilis Ntziachristos, Vasilis Ntziachristos, Jorge Ripoll, Jorge Ripoll, Joseph P. Culver, Joseph P. Culver, Arjun G. Yodh, Arjun G. Yodh, Britton Chance, Britton Chance, Manuel Nieto-Vesperinas, Manuel Nieto-Vesperinas, } "Effect of multiple layers on diffuse optical tomography", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434478; https://doi.org/10.1117/12.434478
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