Image reconstruction from experimental measurements of a multichannel time-resolved optical tomographic imaging system

Feng Gao; H. Zhao; Y. Onodera; Angelo Sassaroli; Yukari Tanikawa; Yukio Yamada

doi:10.1117/12.434513

29 June 2001 Image reconstruction from experimental measurements of a multichannel time-resolved optical tomographic imaging system

Feng Gao, H. Zhao, Y. Onodera, Angelo Sassaroli, Yukari Tanikawa, Yukio Yamada

Author Affiliations +

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434513
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

An optical tomographic imaging system that is composed of 32 near infrared time-resolved spectroscopic channels has been newly implemented for the experimental evaluation of diffuse optical imaging schemes. This article reports on some initial results reconstructed from the transmitted measurement of such a time-resolved system. Two cylindrical tissue-like phantoms having two- and three-dimensional interior structures respectively are employed for the validation of the reconstruction algorithm, which uses the diffusion-based photon migration model and an optimization-based reconstruction solver. We compare the performances of the proposed two- and semi three-dimensional algorithms in reconstructing two-dimensional phantom and demonstrate the ability of full three-dimensional algorithm to simultaneously image multiple slices of there-dimensional phantom, using absolute and/or differential imaging schemes. Also addressed are some technical issues on the calibrations of the time-resolved measurements for matching the photon migration model and alleviating the influence of the inconsistency of the detecting channels. Our reconstructions show that the image quality can be significantly improved by differential imaging scheme that takes radio or difference of the real and reference measurement as the data type. Moreover, the results demonstrate the feasibility of experimental reconstruction from absolute mean time of flight of the temporal measurement, and argue that finer adjustments for the consistency of the detecting channels are necessary to improve the image quality of the absolute reconstruction.

Citation Download Citation

Feng Gao, H. Zhao, Y. Onodera, Angelo Sassaroli, Yukari Tanikawa, and Yukio Yamada "Image reconstruction from experimental measurements of a multichannel time-resolved optical tomographic imaging system", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434513

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