29 June 2001 Interplay of tumor vascular oxygenation and pO2 in tumors using NIRS and needle electrode
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Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434524
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States
Abstract
The effective measurement of dynamic changes of blood and tissue oxygenation of tumors could be valuable for optimizing tumor treatment plans. For this study, a near- infrared spectroscopy system and pO2 needle electrode were used to measure simultaneously changes in total hemoglobin concentration ([Hb]total), oxygenated hemoglobin concentration ([HbO2[) and local oxygen tension (pO2) in the vascular bed of prostate tumors implanted in rats in response to respiratory challenge. The inhaled gas was alternated between air and carbogen (95% oxygen, 5% CO2). Significant changes in tumor vascular oxygenation were observed with an apparent threshold for variation in [HbO2]/[HbO2]max. For comparison, a phantom study was undertaken with 1% intralipid solution and blood. The slope of [HbO2]/[HbO2[max vs. pO2 in the phantom was ten times larger than in the tumor indicating that tumor cells are relatively resistant to oxygenation. This study demonstrates that the NIR technology can provide an efficient, real-time, non-invasive approach to monitoring tumor physiology and is compatible with additional techniques.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jae Gwan Kim, Jae Gwan Kim, Yulin Song, Yulin Song, Dawen Zhao, Dawen Zhao, Anca Constantinescu, Anca Constantinescu, Ralph P. Mason, Ralph P. Mason, Hanli Liu, Hanli Liu, } "Interplay of tumor vascular oxygenation and pO2 in tumors using NIRS and needle electrode", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434524; https://doi.org/10.1117/12.434524
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