29 June 2001 Near-infrared optical imager for cerebral blood flow and oxygenation detection
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Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434516
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States
This paper describes the theory and the apparatus on our newly developed 64 channel optical imager that enables imaging of three components, indocyanine green (ICG), oxyHb and deoxyHb. Knowledge on blood flow is obtainable using ICG as a blood flow indicator that is to be introduced via injection. ICG has a strong absorption at 805nm, therefore the changes in ICG is detectable with NIR spectroscopy separating from oxyHb and deoxyHb using proper three wavelengths. In addition to the system description, it describes an animal experiment and a phantom test for the validation study. It discusses independence features of ICG on Hb values. Using a simple quasi Lambert Beer's law, it proved the excellent separation of the three components. It also discusses the factors that affect the performance of signal separation.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Ichiro Oda, Ichiro Oda, Yukihisa Wada, Yukihisa Wada, Sadao Takeuchi, Sadao Takeuchi, Yukio Oikawa, Yukio Oikawa, Naojumi Sakauchi, Naojumi Sakauchi, Yasunobu Ito, Yasunobu Ito, Ikuo Konishi, Ikuo Konishi, Yoshio Tsunazawa, Yoshio Tsunazawa, Takashi Kusaka, Takashi Kusaka, Kenichi Isobe, Kenichi Isobe, Susumu Itoh, Susumu Itoh, Shoju Onishi, Shoju Onishi, } "Near-infrared optical imager for cerebral blood flow and oxygenation detection", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434516; https://doi.org/10.1117/12.434516

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