Three-dimensional optical tomographic localization of changes in absorption coefficients in the human brain

Avraham Bluestone; Gassan S. Abdoulaev; Randall Locke Barbour; Christoph H. Schmitz; Andreas H. Hielscher

doi:10.1117/12.434496

29 June 2001 Three-dimensional optical tomographic localization of changes in absorption coefficients in the human brain

Avraham Bluestone, Gassan S. Abdoulaev, Randall Locke Barbour, Christoph H. Schmitz, Andreas H. Hielscher

Author Affiliations +

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434496
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

We report on the first three dimensional tomographic localization of vascular reactivity in the brain. Using a model-based iterative image reconstruction algorithm we show volumetric spatial changes in the absorption coefficient caused by changes in blood volume. Unlike currently available topographic reconstruction techniques, volumetric reconstruction schemes promise to be capable of spatially distinguishing between signals originating in the cerebral cortex from those originating in the overlying vascular tissues.

Citation Download Citation

Avraham Bluestone, Gassan S. Abdoulaev, Randall Locke Barbour, Christoph H. Schmitz, and Andreas H. Hielscher "Three-dimensional optical tomographic localization of changes in absorption coefficients in the human brain", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434496

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