23 May 2001 In-vivo evaluation of locally mapped refractive indices with OCT
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Proceedings Volume 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V; (2001); doi: 10.1117/12.427884
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States
Abstract
Besides morphological images created by optical coherence tomography (OCT), another inherent physical parameter is evaluated in skin tissue under in vivo conditions. Refractive indices may support tissue characterization for research and diagnostic purposes in cosmetics/pharmacy and medicine, respectively. To accomplish refractive index evaluation, the sample arm of our OCT setup has been arranged to minimize mechanical adjustment and yet accommodate a wide parameter range at the entire penetration depth of up to 1 mm. A simple algorithm for local mapping has been derived. Refractive index maps have been measured locally in skin of stratum corneum, epidermis and upper parts of the dermis. Dry and moist skin areas have been observed by refractive index evaluation.
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Alexander R. Knuettel, Slavtcho Bonev, Christian Kugler, "In-vivo evaluation of locally mapped refractive indices with OCT", Proc. SPIE 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V, (23 May 2001); doi: 10.1117/12.427884; https://doi.org/10.1117/12.427884
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KEYWORDS
Refractive index

Optical coherence tomography

Skin

In vivo imaging

Scattering

Spatial resolution

Light scattering

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