Detection of malignant tissues by using infrared microscopy and fiber optic spectroscopy

Uwe Bindig; Martina Meinke; Ingo H. Gersonde; Sergei Kravchik; Samuel Citron; Abraham Katzir; Gerhard J. Mueller

doi:10.1117/12.427922

4 June 2001 Detection of malignant tissues by using infrared microscopy and fiber optic spectroscopy

Uwe Bindig, Martina Meinke, Ingo H. Gersonde, Sergei Kravchik, Samuel Citron, Abraham Katzir, Gerhard J. Mueller

Proceedings Volume 4253, Optical Fibers and Sensors for Medical Applications; (2001) https://doi.org/10.1117/12.427922
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

In this work we present our effort to develop an infrared method to differentiate between malignant and healthy tissue in vivo. This paper will present the technical design of the laboratory set up and the results obtained in experiments carried out on melanoma tumors in the skin of male mice. Silver halide fibers were used to carry our ATR measurements on tumor sections. Further results were compared with detailed measurements carried out using an FTIR-microscope and thin tissue sections in the spectral range of 4000 - 900 cm^-1. The results indicate that IR spectroscopy would be a useful tool for biodiagnosis, in vivo and in real time. The fiberoptic method described here will easily lend itself to endoscopic applications.

Citation Download Citation

Uwe Bindig, Martina Meinke, Ingo H. Gersonde, Sergei Kravchik, Samuel Citron, Abraham Katzir, and Gerhard J. Mueller "Detection of malignant tissues by using infrared microscopy and fiber optic spectroscopy", Proc. SPIE 4253, Optical Fibers and Sensors for Medical Applications, (4 June 2001); https://doi.org/10.1117/12.427922

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