In this paper, we first report experiments on confocal tomography of sonoluminescence media with objects buried in both biological tissue and tissue-simulating media. A high-sensitive confocal scanning setup based on photon counting technique was developed. With the system, a carbon cube buried in tissue simulation medium was imaged with high contrast and a lateral resolution of about 100μm. For the tissue experiment a carbon stick buried in muscle tissue was optically sectioned with the sonoluminescence confocal scanning technique. The spatial resolution of the image at present is limited by the intensity of the sonoluminescence, and could be largely improved by increasing the intensity of emission by a sono-chemluminescence method. The optical tomography of sono-chemluminescence method has potential applications in clinical diagnosis.