Spatially-resolved cerebral blood flow imaging using laser speckle

Andrew K. Dunn; Hayrunnisa Bolay; Michael J. Moskowitz; David A. Boas

doi:10.1117/12.426780

10 May 2001 Spatially resolved cerebral blood flow imaging using laser speckle

Andrew K. Dunn, Hayrunnisa Bolay, Michael J. Moskowitz, David A. Boas

Proceedings Volume 4260, Optical Diagnostics of Living Cells IV; (2001) https://doi.org/10.1117/12.426780
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Cerebral blood flow measurements are crucial for studying neuronal activity and cerebrovascular responses. Most optical techniques for monitoring real time blood flow rely on laser Doppler measurements which are limited to a localized region in space (point measurements). We have used the time-varying speckle pattern produced by coherent light scattered from moving particles to provide real-time, two-dimensional maps of capillary blood flow dynamics. The speckle images of relative blood flow during cortical spreading depression showed a 2-3 mm area of increased blood flow propagation with a velocity of 2.5 mm/min. The speckle technique therefore, provides a relatively simple method of obtaining spatially resolved cerebral blood flow changes in the exposed cortex with high temporal resolution (milliseconds).

Citation Download Citation

Andrew K. Dunn, Hayrunnisa Bolay, Michael J. Moskowitz, and David A. Boas "Spatially resolved cerebral blood flow imaging using laser speckle", Proc. SPIE 4260, Optical Diagnostics of Living Cells IV, (10 May 2001); https://doi.org/10.1117/12.426780

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