13 June 2001 Development of an implantable skin port sensor for use as an in-vivo optical glucose sensing platform
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Proceedings Volume 4263, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring; (2001) https://doi.org/10.1117/12.429333
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States
Abstract
Factors that have limited the acceptance of optical spectroscopy methods for non-invasive blood glucose sensing include signal variations due in part to changes in the skin tissue optics between patients, the lack of a repeatable pathlength inherent in using diffusely reflected photon approaches, temperature variations on the skin, and the pressure with which a probe is applied to the skin surface. Unfortunately, most previous approaches to non-invasive glucose sensing have failed to address these important issues. In this work, we developed a novel skin port sensor (SPS) which eliminates the effect of skin optics by using a stable, infection-free, dermal implant to provide a skinless window into the body. Our implant is designed to provide a fixed optical pathlength as well as features to minimize temperature and pressure variations. Preliminary experiments in a pig model demonstrate both a stable biological seal at the transcutaneous interface as well as ingrowth of vascular containing granulation tissue within the sensing chamber. Furthermore, optical spectra acquired from the port demonstrate changes in glucose signatures related to concentration changes induced in the blood. Our novel SPS may provide the necessary platform for successful implementation of an optical approach to in vivo glucose sensing.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Ashok Gowda, Ashok Gowda, Roger J. McNichols, Roger J. McNichols, Theresa W. Fossum, Theresa W. Fossum, Sohi Rastegar, Sohi Rastegar, Gerard L. Cote, Gerard L. Cote, } "Development of an implantable skin port sensor for use as an in-vivo optical glucose sensing platform", Proc. SPIE 4263, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring, (13 June 2001); doi: 10.1117/12.429333; https://doi.org/10.1117/12.429333
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