21 May 2001 Detection of pathogens using on-chip electrochemical analysis of PCR amplified DNA molecules
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Proceedings Volume 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology; (2001) https://doi.org/10.1117/12.427958
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States
Abstract
The sensitivity and speed of methods for the detection of microorganisms and/or cells need to be constantly improved to provide timely and accurate analysis in large number of important applications. Such applications range from detection of pathogens in drinking water, biological warfare agents, biomedical diagnostics and food industry. The trends toward miniaturization of sensors using microfluidic and nanofluidic on-chip devices will push current detection limits to lower concentrations than what is offered by the present analytical equipment and/or detection kids. Microfluidic devices have been used to perform DNA analysis, polymerase chain reaction analysis, capillary electrophoresis and hybridization to oligonucleotide probes. This paper describes a new approach for the detection of pathogens on contaminated surfaces, which will integrated sampling, concentration and detection of targeted microorganisms.
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Dalibor Hodko, Dalibor Hodko, Lindsay Raymer, Lindsay Raymer, Stephanie M. Herbst, Stephanie M. Herbst, James W. Magnuson, James W. Magnuson, David Gaskin, David Gaskin, } "Detection of pathogens using on-chip electrochemical analysis of PCR amplified DNA molecules", Proc. SPIE 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology, (21 May 2001); doi: 10.1117/12.427958; https://doi.org/10.1117/12.427958
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