21 May 2001 Semiconductor microcavity laser spectroscopy of intracellular protein in human cancer cells
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Proceedings Volume 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology; (2001) https://doi.org/10.1117/12.427967
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States
Abstract
The speed of light through a biofluid or biological cell is inversely related to the biomolecular concentration of proteins and other complex molecules comprising carbon- oxygen double bonds that modify the refractive index at wavelengths accessible to semiconductor lasers. By placing a fluid or cell into a semiconductor microcavity laser, these decreases in light speed can be sensitively recorded in picoseconds as frequency red-shifts in the laser output spectrum. This biocavity laser equipped with microfluidics for transporting cells at high speed through the laser microcavity has shown potential for rapid analysis of biomolecular mass of normal and malignant human cells in their physiologic condition without time-consuming fixing, staining, or tagging.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Paul Lee Gourley, Paul Lee Gourley, Jimmy D. Cox, Jimmy D. Cox, Judy Kay Hendricks, Judy Kay Hendricks, Anthony E. McDonald, Anthony E. McDonald, G. C. Copeland, G. C. Copeland, Darryl Y. Sasaki, Darryl Y. Sasaki, Mark S. Curry, Mark S. Curry, Steven K. Skirboll, Steven K. Skirboll, } "Semiconductor microcavity laser spectroscopy of intracellular protein in human cancer cells", Proc. SPIE 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology, (21 May 2001); doi: 10.1117/12.427967; https://doi.org/10.1117/12.427967
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