With the development of high-speed CMOS imagers, it is possible to acquire and process multiple images within the imager, prior output. We refer to an imaging architecture that acquires a collection of images and produces a single result as multiple capture single image (MCSI). In this paper we describe some applications of the MCSI architecture using a monochrome sensor and modulation light sources. By using active light sources. By using active light sources, it is possible to measure object information in a manner that is independent of the passive illuminant. To study this architecture, we have implemented a test system using a monochrome e CMOS sensor and several arrays of color LEDs whose temporal modulation can be precisely controlled. First, we report on experimental measurement that evaluate how well the active and passive illuminant can be separated as a function of experimental variables, including passive illuminant intensity, temporal sampling rate and modulation amplitude. Second, we describe two applications of this technique: (a) creating a color image from a monochrome sensor, and (b) measuring the spatial distribution of the passive illuminant.