3 July 2001 3D image guidance in radiotherapy: a feasibility study
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Currently, one major research field in radiotheraphy is focused on patient setup verification and on detection of organ motion and deformation. A phantom study is performed to demonstrate the feasibility of image guidance in radiotherapy. Patient setup errors are simulated with a humanoid phantom, which is imaged using a linear accelerator and a therapy simulator to address megavoltage and kilovoltage (kV) computed tomography (CT), respectively. Projections are recorded by a flat panel imager. The various data sets of the humanoid phantom are compared by mutual information matching. The CT investigations show that the spatial resolution is better than 1.6 mm for high contrast objects. The uncertainties remaining after mutual information matching are found to be less than 1 mm for translations and 1 degree(s) for rotations. The phantom study indicates that the detection of patient setup errors as well as organ motion or deformation is possible with a high accuracy, especially if a kV X-ray tube could be attached to the linear accelerator. The presented method allows sophisticated quality assurance of beam delivery in each fraction and may even enable the use of new concepts of adaptive radiotherapy.
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Matthias Ebert, Matthias Ebert, Burkhard A. Groh, Burkhard A. Groh, Mike Partridge, Mike Partridge, Bernd M. Hesse, Bernd M. Hesse, Thomas Bortfeld, Thomas Bortfeld, } "3D image guidance in radiotherapy: a feasibility study", Proc. SPIE 4322, Medical Imaging 2001: Image Processing, (3 July 2001); doi: 10.1117/12.431070; https://doi.org/10.1117/12.431070

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