Characterizing populations and searching for diagnostics via elastic registration of MRI images

David Pettey; James C. Gee

doi:10.1117/12.431049

3 July 2001 Characterizing populations and searching for diagnostics via elastic registration of MRI images

David Pettey, James C. Gee

Proceedings Volume 4322, Medical Imaging 2001: Image Processing; (2001) https://doi.org/10.1117/12.431049
Event: Medical Imaging 2001, 2001, San Diego, CA, United States

Abstract

Given image data from two distinct populations and a family of functions, we find the scalar discriminant function which best discriminates between the populations. The goals are two-fold: first, to construct a discriminant function which can accurately and reliably classify subjects via the image data. Second, the best discriminant allows us to see which features in the images distinguish between the populations; these features can guide us to finding characteristic differences between the two groups even if these differences are not sufficient to perform classification. We apply our method to mid-sagittal MRI sections of the corpus callosum from 34 males and 52 females. While we are not certain of the ability of the derived discriminant function to perform sex classification, we find that regions in the anterior of the corpus callosum do appear to be more important for the discriminant function than other regions. This indicates there may be significant differences in the relative size of the splenium in males and females, as has been reported elsewhere. More notably, we applied previous methods which support this view on our larger data set, but found that these methods no longer show statistically significant differences between the male and female splenium.

Citation Download Citation

David Pettey and James C. Gee "Characterizing populations and searching for diagnostics via elastic registration of MRI images", Proc. SPIE 4322, Medical Imaging 2001: Image Processing, (3 July 2001); https://doi.org/10.1117/12.431049

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