Two alternative forced-choice (2AFC) nodule detection performances of a number of model observers were evaluated for detection of simulated nodules in filtered power-law (1/f3) noise. The models included the ideal observer, the channelized Fisher-Hotelling (FH) model with two different basis function sets, the non-prewhitening matched filter with an eye filter (NPWE), and the Rose model with no DC response (RoseNDC). Detectability of the designer nodule signal was investigated. It has equation s((rho) )equalsA*Rect((rho) /2)(1-(rho) 2)v, where (rho) is a normalized distance (r/R), R is the nodule radius and A is signal amplitude. The nodule profile can be changed (designed) by changing the value of v. For example, the result is a sharp-edged, flat-topped disc for v equal to zero and the projection of a sphere for v equal to 0.5. Human observer experiments were done with nodules based on v equal to 0, 0.5 and 1.5. For the v equal to 1.5 case, human results could be well fitted using a variety of models. The human CD diagram slopes were -0.12, +0.27 and +0.44 for v equal to 0, 0.5 and 1.5 respectively.