14 September 2001 Salt-bridge-supported bilayer lipid membrane biosensor for determination of anticancer drug cyclophosphamide
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Proceedings Volume 4414, International Conference on Sensor Technology (ISTC 2001); (2001) https://doi.org/10.1117/12.440176
Event: International Conference on Sensing units and Sensor Technology, 2001, Wuhan, China
Abstract
A novel biosensor for assaying anticancer drug cyclophosphamide was constructed with salt-bridge supported bilayer lipid membrane modified with tetraphenylborate- cyclophosphamide complex. The modification was achieved by the introduction of the complex into the membrane forming solution. The biosensor show a linear response to the drug over the concentration range 8.96 X 10-6 mol L-1. The effects of coexistent substances and pH on assay were evaluated. The results show that the distinguish merits of this kind of biosensor is the excellently biological compatibility and no need of mediator for ions exchange. It also shows good selectivity and sensitivity for cyclophosphamide assay.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yanli Zhang, Yanli Zhang, Tao Wang, Tao Wang, Chunxu Zhang, Chunxu Zhang, Hanxi Shen, Hanxi Shen, Fuhuan Chao, Fuhuan Chao, } "Salt-bridge-supported bilayer lipid membrane biosensor for determination of anticancer drug cyclophosphamide", Proc. SPIE 4414, International Conference on Sensor Technology (ISTC 2001), (14 September 2001); doi: 10.1117/12.440176; https://doi.org/10.1117/12.440176
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