22 August 2001 Microinvasive laser surgery for laryngeal carcinoma
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Proceedings Volume 4427, Imaging of Tissue Structure and Function; (2001) https://doi.org/10.1117/12.438422
Event: Imaging of Tissue Structure and Function, 2001, none, Russian Federation
Abstract
Objective: To investigate the effectiveness of microinvasive Nd:YAG laser surgery in case of early stage laryngeal carcinoma as well as it's effect on the cellular immune function of the tumor-bearing hosts. Material and Method: Thirty-seven patients with glottic Tis or T1 SCC were treated by fiberoptic laryngoscopic Nd:YAG laser surgery. Both before and after therapy, serum levels of soluble interleukin-2 receptor (SIL-2R) and interleukin- 2(IL-2) as well as the NK activity were determined via double-antibody sandwich technique, tritiated thymidine- deoxyribonucleoside incorporation and iodine 125-uridine- deoxyribunocleoside release technique, respectively. Result: All 37 patients tolerated the procedure well. A 3-8 year follow up in a subgroup of 31 patients resulted in a estimated cure rate of 87.1% (27/31). The posttherapy serum levels of SIL-2R were significantly declined (p<0.001), while those of IL-2 and NK activity were significantly elevated (p<0.001) as compared with those detected pretherapeutically. Conclusion: Therapy with fiberoptic laryngoscopic Nd:YAG laser surgery is simple, safe, effective and microinvasive for the patients with early stage laryngeal carcinoma and has an immuno-enhancing effect on its host.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jinping Lai, Jinping Lai, Zhengde Tao, Zhengde Tao, Jianyun Xiao, Jianyun Xiao, Junli Luo, Junli Luo, Xianghui Chen, Xianghui Chen, Suping Zhao, Suping Zhao, Christian Betz, Christian Betz, } "Microinvasive laser surgery for laryngeal carcinoma", Proc. SPIE 4427, Imaging of Tissue Structure and Function, (22 August 2001); doi: 10.1117/12.438422; https://doi.org/10.1117/12.438422
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