2 November 2001 Three-dimensional optical tomographic imaging of vascular reactivity in the brain
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Abstract
We report on the first three-dimensional, volumetric, tomographic localization of changes in the concentration of oxyhemoglobin and deoxyhemoglobin in the brain. To this end we have developed a model-based iterative image reconstruction scheme that employs adjoint differentiation methods to minimize the difference between measured and predicted data. To illustrate the performance of the technique, the three-dimensional distribution of changes in the concentration of oxyhemoglobin and deoxyhemoglobin during a Valsalva maneuver are visualized. The observed results are consistent with previously reported effects concerning optical responses to hemodynamic perturbations.
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Andreas H. Hielscher, Andreas H. Hielscher, Avraham Bluestone, Avraham Bluestone, Gassan S. Abdoulaev, Gassan S. Abdoulaev, Joseph Lasker, Joseph Lasker, Randall Locke Barbour, Randall Locke Barbour, Christoph H. Schmitz, Christoph H. Schmitz, } "Three-dimensional optical tomographic imaging of vascular reactivity in the brain", Proc. SPIE 4431, Photon Migration, Optical Coherence Tomography, and Microscopy, (2 November 2001); doi: 10.1117/12.447424; https://doi.org/10.1117/12.447424
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