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31 October 2001 Optical biopsy for the diagnosis of dysplasia in Barrett's oesophagus
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Barrett's oesophagus is an increasingly common pre-cancerous condition, which occurs in patients suffering from acid reflux into their gullet. Biopsies must be taken from patients diagnosed with this condition regularly to pick up signs of pre-cancerous changes. Elastic scattering spectroscopy offers the possibility of distinguishing between benign and pre-cancerous changes in the lower oesophagus with a relatively simple optical measurement. This optical biopsy is correlated with a conventional histopathological specimen obtained at the same point. It is shown that to a relatively high degree of sensitivity and specificity it is possible to distinguish between pre-malignant patches, benign lesions and normal tissue.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
David C. O. Pickard, Irving J. Bigio, Stephen G. Bown, Laurence B. Lovat, Paul M. Ripley, and Marco Novelli "Optical biopsy for the diagnosis of dysplasia in Barrett's oesophagus", Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001);

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