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31 October 2001 Trimodal spectroscopy as a tool for detecting cervical squamous intraepithelial lesions in vivo
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Abstract
Using intrinsic fluorescence, diffuse reflectance and light scattering spectroscopy we extracted quantitative biochemical and morphological information in vivo about the bulk tissue and the epithelial cell nuclei of ectocervical sites from 44 patients. Significant changes were observed in tissue morphology and biochemistry between normal, squamous metaplastic and squamous intraepithelial lesion (SIL) sites. The combined use of all three spectroscopic techniques (tri-modal spectroscopy) yielded superior results for detecting SILs than any one of the techniques alone.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Irene Georgakoudi, Ellen E. Sheets, Christopher P. Crum, Markus G. Mueller, Vadim Backman, and Michael S. Feld "Trimodal spectroscopy as a tool for detecting cervical squamous intraepithelial lesions in vivo", Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001); https://doi.org/10.1117/12.447118
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