Application of phosphorescence quenching by O2 to the investigation of O2 delivery to ocular tissues

Stephane R. Chamot; Benno L. Petrig; Constantin J. Pournaras; Christine L. Percicot; George N. Lambrou; Charles E. Riva

doi:10.1117/12.446498

26 October 2001 Application of phosphorescence quenching by O₂ to the investigation of O₂ delivery to ocular tissues

Stephane R. Chamot, Benno L. Petrig, Constantin J. Pournaras, Christine L. Percicot, George N. Lambrou, Charles E. Riva

Proceedings Volume 4433, Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy; (2001) https://doi.org/10.1117/12.446498
Event: European Conferences on Biomedical Optics, 2001, Munich, Germany

Abstract

The technique of phosphorescence quenching by O₂ (PQ) allows the non-invasive measurement of the partial pressure of oxygen in blood (pO₂^blood). This technique and its application to the investigation of the pO₂^blood in the microvasculature of the retina and optic nerve head (ONH) of two animal species is described. Using the imaging mode of PQ, 2-dimensional pO₂^blood maps were obtained to investigate the response of the pO₂^blood to various physiological stimuli in miniature pigs and the effect of experimental glaucoma in monkeys. Applied in its focal mode, PQ allows measurements of the pO₂^blood with a time resolution of 1 second and is adequate to investigate the pO₂^blood time course during light stimulation.

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Stephane R. Chamot, Benno L. Petrig, Constantin J. Pournaras, Christine L. Percicot, George N. Lambrou, and Charles E. Riva "Application of phosphorescence quenching by O₂ to the investigation of O₂ delivery to ocular tissues", Proc. SPIE 4433, Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy, (26 October 2001); https://doi.org/10.1117/12.446498

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