3D micro-CT analysis of cancellous bone architecture

Massimo Rossi; Franco Casali; Davide Romani; Maria Letizia Carabini

doi:10.1117/12.452863

7 January 2002 3D micro-CT analysis of cancellous bone architecture

Massimo Rossi, Franco Casali, Davide Romani, Maria Letizia Carabini

Proceedings Volume 4503, Developments in X-Ray Tomography III; (2002) https://doi.org/10.1117/12.452863
Event: International Symposium on Optical Science and Technology, 2001, San Diego, CA, United States

Abstract

Osteoporosis is the most common type of metabolic bone disease generating morphological alterations of the bone structure. Therefore, an intensive and accurate study of cancellous bone architecture is required to individuate the origin of the disease and to estimate its evolution. For this purpose, a specific project is in progress at the Physics Department of Bologna to carry out microtomography analysis in vitro of animal bone samples. The inspection system mainly consists of an X-ray microfocus source to irradiate the sample and of a CCD-based detector for the detection of the radiographic image. A sample with a diameter up to 30 mm and a height of 15 mm can be investigated over its whole volume. Three-dimensional images of the bone structure can be obtained with a spatial resolution variable from 30 up to few microns. A pig bone specimen has been investigated to test the equipment and to carry out intensive analysis and modeling of bone architecture. Moreover, a specific volume data processing procedure has been developed and tested to extract morphometric measurements of the bone structure.

Citation Download Citation

Massimo Rossi, Franco Casali, Davide Romani, and Maria Letizia Carabini "3D micro-CT analysis of cancellous bone architecture", Proc. SPIE 4503, Developments in X-Ray Tomography III, (7 January 2002); https://doi.org/10.1117/12.452863

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