7 January 2002 Medical imaging by fluorescent x-ray CT: its preliminary clinical evaluation
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Fluorescent x-ray CT (FXCT) with synchrotron radiation (SR) is being developed to detect the very low concentration of specific elements. The endogenous iodine of the human thyroid and the non-radioactive iodine labeled BMIPP in myocardium were imaged by FXCT. FXCT system consists of a silicon (111) double crystal monochromator, an x-ray slit, a scanning table for object positioning, a fluorescent x-ray detector, and a transmission x-ray detector. Monochromatic x-ray with 37 keV energy was collimated into a pencil beam (from 1 mm to 0.025 mm). FXCT clearly imaged endogenous iodine of thyroid and iodine labeled BMIPP in myocardium, whereas transmission x-ray CT could not demonstrate iodine. The distribution of iodine was heterogeneous within thyroid cancer, and its concentration was lower than that of normal thyroid. Distribution of BMIPP in normal rat myocardium was almost homogeneous; however, reduced uptake was slightly shown in ischemic region. FXCT is a highly sensitive imaging modality to detect very low concentration of specific element and will be applied to reveal endogenous iodine distribution in thyroid and to use tracer study with various kinds of labeled material.
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Tohoru Takeda, Tohoru Takeda, Tsutomu Zeniya, Tsutomu Zeniya, Jin Wu, Jin Wu, Quanwen Yu, Quanwen Yu, Thet Thet Lwin, Thet Thet Lwin, Yoshinori Tsuchiya, Yoshinori Tsuchiya, Donepudi V. Rao, Donepudi V. Rao, Tetsuya Yuasa, Tetsuya Yuasa, Toru Yashiro, Toru Yashiro, F. Avraham Dilmanian, F. Avraham Dilmanian, Yuji Itai, Yuji Itai, Takao Akatsuka, Takao Akatsuka, } "Medical imaging by fluorescent x-ray CT: its preliminary clinical evaluation", Proc. SPIE 4503, Developments in X-Ray Tomography III, (7 January 2002); doi: 10.1117/12.452856; https://doi.org/10.1117/12.452856

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