Diagnostic potential of ultraviolet laser-induced autofluorescence of stomach tissues

B. W. Chwirot; S. Chwirot; W. Jedrzejczyk; M. Jackowski; Z. Michniewicz; A. M. Raczynska; J. Winczakiewicz; J. Dobber

doi:10.1117/12.432961

11 July 2001 Diagnostic potential of ultraviolet laser-induced autofluorescence of stomach tissues

B. W. Chwirot, S. Chwirot, W. Jedrzejczyk, M. Jackowski, Z. Michniewicz, A. M. Raczynska, J. Winczakiewicz, J. Dobber

Proceedings Volume 4515, Light and Optics in Biomedicine; (2001) https://doi.org/10.1117/12.432961
Event: Light and Optics in Biomedicine, 2000, Warsaw, Poland

Abstract

Images of the laser-induced fluorescence (325 nm, He-Cd laser) were recorded in vitro in six regions of a visible spectrum using a cooled CCD camera. Images were taken sequentially and then processed to assess the ability of such an approach to detect and to localize cancer tissues. 72 areas of 21 resected specimens were examined. It has been established that a difference of fluorescence intensities measured at 440 nm and 395 nm, both normalized to intensity measured at 590 nm differs significantly for the neoplastic and non-neoplastic tissues of interest. Using this quantity as a diagnostic parameter it was possible to classify malignant gastric tissues with a sensitivity of 96% and a specificity of 42% while the same approach applied to abnormal stomach tissues gave respectively values of 80% and 98%.

Citation Download Citation

B. W. Chwirot, S. Chwirot, W. Jedrzejczyk, M. Jackowski, Z. Michniewicz, A. M. Raczynska, J. Winczakiewicz, and J. Dobber "Diagnostic potential of ultraviolet laser-induced autofluorescence of stomach tissues", Proc. SPIE 4515, Light and Optics in Biomedicine, (11 July 2001); https://doi.org/10.1117/12.432961

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