12 April 2002 Calibration of tissue optical properties for I&Q phase detection system using multiwavelength fitting model
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Proceedings Volume 4536, International Workshop on Photonics and Imaging in Biology and Medicine; (2002); doi: 10.1117/12.462548
Event: International Workshop on Photonics and Imaging in Biology and Medicine, 2001, Wuhan, China
Abstract
In-phase and Quadrature Phase Detection System (I&Q System) can be used to detect the clinic-related parameters such as hemoglobin concentration and saturation. We set up an effective multi-wavelength fitting model and method to calibrate the tissue optical properties such as the reduced scattering factor ((mu) s) and the absorption factor ((mu) a), which can be calculated from the measured amplitude and phase shift of I&Q system. Then using the calibrated tissue optical parameters, we can get better results for hemoglobin concentration and saturation by our proposed algorithm of fitting multi-wavelength absorption coefficient ((mu) a) of the medium than those from the previous I&Q system based on the two-wavelength absorption coefficient calculation. Our algorithm is used in the clinical experiments with five wavelengths (680 nm, 750 nm, 780 nm, 810 nm, 830 nm) for the necks' and arms' saturation test between normal persons and tumor-bearing patients.
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Ping Huang, Shoko Nioka, Britton Chance, "Calibration of tissue optical properties for I&Q phase detection system using multiwavelength fitting model", Proc. SPIE 4536, International Workshop on Photonics and Imaging in Biology and Medicine, (12 April 2002); doi: 10.1117/12.462548; http://dx.doi.org/10.1117/12.462548
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KEYWORDS
Calibration

Scattering

Absorption

Tissue optics

Phase measurement

Tissues

Neck

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