Animal on a chip: a microscale cell culture analog device for evaluating toxicological and pharmacological profiles

Aaron Sin; Gregory T. Baxter; Michael L. Shuler

doi:10.1117/12.443045

28 September 2001 Animal on a chip: a microscale cell culture analog device for evaluating toxicological and pharmacological profiles

Aaron Sin, Gregory T. Baxter, Michael L. Shuler

Author Affiliations +

Proceedings Volume 4560, Microfluidics and BioMEMS; (2001) https://doi.org/10.1117/12.443045
Event: Micromachining and Microfabrication, 2001, San Francisco, CA, United States

Abstract

With the increasing rate of discovery of new potential pharmaceuticals, an accurate high throughput screening method is needed to provide toxicology and pharmcology profiles of chemicals. This can be done using a cell culture analog device which uses interconnected tissue cultures to represent different organ systems in animals. A working prototype of microscale cell culture analog (CCA) device has been constructed. Cells cultured in the system have been shown to be viable for more than 24 hours. In this paper, we will present the development of this microscale CCA device as well as the integratable micropump we have created to produce the recirculating flow.

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Aaron Sin, Gregory T. Baxter, and Michael L. Shuler "Animal on a chip: a microscale cell culture analog device for evaluating toxicological and pharmacological profiles", Proc. SPIE 4560, Microfluidics and BioMEMS, (28 September 2001); https://doi.org/10.1117/12.443045

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