25 October 2001 Autofluorescence diagnostic algorithm for detecting malignant colonic tissues
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Proceedings Volume 4597, Biophotonics Instrumentation and Analysis; (2001) https://doi.org/10.1117/12.446650
Event: International Symposium on Photonics and Applications, 2001, Singapore, Singapore
Abstract
The ratio of autofluorescence intensity at 550+/- 10 nm to that at 630+/- 10 nm (R1=I550/I630) or 680+/- 10 nm (R2=I550/I680) was used as a diagnostic algorithm for identification of malignant tumour tissues. The performance of the ratio diagnostic algorithm was evaluated on more than 100 human colonic specimens under excitation laser light at 457.9 nm. A significant difference of the ratio value R1 and R2 was found between normal and tumour specimens (p<0.001). The diagnostic test has a sensitivity and specificity of 85% and 87% for a threshold value of R1=1.75, and a sensitivity and specificity of 94% and 82% for a threshold of R2=3.5. The experimental results show that the ratio mapping is sensitive to the small changes in the presence of tumour tissues, and the contrast of the contour map for detecting the region of malignancy can also be enhanced significantly if using the diagnostic algorithm R2 (I550/I680).
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Zhiwei Huang, Zhiwei Huang, Wei Zheng, Wei Zheng, Teck-Chee Chia, Teck-Chee Chia, Cheong Hoong Diong, Cheong Hoong Diong, Tuan-Kay Lim, Tuan-Kay Lim, Francis Choen Seow, Francis Choen Seow, Haishan Zeng, Haishan Zeng, Calum E. MacAulay, Calum E. MacAulay, D. I. Maclean, D. I. Maclean, Harvey Lui, Harvey Lui, } "Autofluorescence diagnostic algorithm for detecting malignant colonic tissues", Proc. SPIE 4597, Biophotonics Instrumentation and Analysis, (25 October 2001); doi: 10.1117/12.446650; https://doi.org/10.1117/12.446650
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