Endoscopy imaging of 5-ALA-induced PPIX fluorescence for detecting early neoplasms in the oral cavity

Wei Zheng; Malini Olivo; Ranjiv Sivanandan; Philip Karuman; Tuan-Kay Lim; K. Chee Soo

doi:10.1117/12.446648

25 October 2001 Endoscopy imaging of 5-ALA-induced PPIX fluorescence for detecting early neoplasms in the oral cavity

Wei Zheng, Malini Olivo, Ranjiv Sivanandan, Philip Karuman, Tuan-Kay Lim, K. Chee Soo

Proceedings Volume 4597, Biophotonics Instrumentation and Analysis; (2001) https://doi.org/10.1117/12.446648
Event: International Symposium on Photonics and Applications, 2001, Singapore, Singapore

Abstract

A digitized fluorescence endoscopy imaging system combined with 5-Aminolevulinic Acid (5-ALA) induced Protoporphyrin IX (PPIX) has been developed for the detection of neoplasms in oral cavity. It mainly consists of the illumination console, fluorescence detection unit, computer system for image acquisition, processing and analysis, and online image display system as well. The developed system can produce both the digital and video fluorescence images in real time, and can be used to quantify fluorescence images acquired. Preliminary results from the Head and Neck clinic show that high sensitivity and high specificity can be achieved. Furthermore, applying the intensity ratios at two different wavelength regions, the developed system shows the capability of differentiating between different histopathological stages of oral lesions, suggesting a significant potential for realizing the non-invasive optical biopsy for early cancer diagnosis.

Citation Download Citation

Wei Zheng, Malini Olivo, Ranjiv Sivanandan, Philip Karuman, Tuan-Kay Lim, and K. Chee Soo "Endoscopy imaging of 5-ALA-induced PPIX fluorescence for detecting early neoplasms in the oral cavity", Proc. SPIE 4597, Biophotonics Instrumentation and Analysis, (25 October 2001); https://doi.org/10.1117/12.446648

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