Investigation of various synthetic polymer scaffolds for enhanced mechanical strength during laser tissue soldering

Grant T. Hoffman; Eric C. Soller; Jill N. Riley; Karen M. McNally-Heintzelman

doi:10.1117/12.432092

17 June 2002 Investigation of various synthetic polymer scaffolds for enhanced mechanical strength during laser tissue soldering

Grant T. Hoffman, Eric C. Soller, Jill N. Riley, Karen M. McNally-Heintzelman

Author Affiliations +

Proceedings Volume 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII; (2002) https://doi.org/10.1117/12.432092
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

An investigation was conducted to assess the feasibility ofusing various synthetic polymers as scaffolds to traditional albumin protein solders with the aim of enhancing the mechanical strength of repairs formed during laser tissue soldering. Biodegradable polymer membranes of controlled porosity were fabricated with either polylactic acid (PLA), polyglycolic acid (PGA), or two different poly(L-lactic-co-glycolic acid) (PLGA) blend ratios, using a solvent-casting and particulate-leaching technique. In addition, membranes were prepared by combining each of the above mentioned polymers with poly(ethylene glycol) (PEG). The porous membranes provided a scaffold into which the traditional protein solder composition of serum albumin and indocyanine green dye mixed in deionized water was readily absorbed. Studies were conducted to assess the influence of various processing parameters on the strength of tissue repairs formed using the new adhesives. These parameters included the polymer type, the polymer/PEG blend ratio, the salt particle size, and the initial albumin weight fraction. No significant difference was observed between the four polymers investigated, however, variation of the polymer type and blend ratio is known to influence the degradation rate of the membranes. The addition of PEG to the films during the casting stage was observed to increase the flexibility of the membranes. Finally, repair strength increased significantly with an increase in the size ofpores present in the membranes and with increased protein concentration.

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Grant T. Hoffman, Eric C. Soller, Jill N. Riley, and Karen M. McNally-Heintzelman "Investigation of various synthetic polymer scaffolds for enhanced mechanical strength during laser tissue soldering", Proc. SPIE 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, (17 June 2002); https://doi.org/10.1117/12.432092

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KEYWORDS

Polymers

Proteins

Tissues

Laser tissue interaction

Laser welding

Particles

Laser applications

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