17 June 2002 Transdermal delivery of photosensitizer by laser-induced stress wave
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Proceedings Volume 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII; (2002) https://doi.org/10.1117/12.432076
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States
Abstract
The skin permeability of most of drugs is low, because the stratum corneum works as a solid barrier. It is required, therefore, to enhance the skin permeability for transdermal delivery of drug. To investigate the effects of heating skin and exposing skin to a laser-induced stress wave (LISW) on the drug permeability, we tried to deliver porfimer sodium into rat’s skin. The experiment was performed under the four different skin conditions; exposing to a LISW (case 1); heating (case 2); exposing to a LISW and heating (case 3); control (case 4). It was observed in all cases except the case 4 (control), the drug permeated into the dermis through the epidermis. The deepest penetration was obtained in the case 3 (a LISW plus heating). It was suggested that heating increased the fluidity of the lipid bilayers in the stratum corneum, and therefore the drug permeability might be enhanced.
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Makoto Ogura, Shunichi Sato, Masahiko Kuroki, Hitoshi Wakisaka, Satoko Kawauchi, Miya Ishihara, Makoto Kikuchi, Masahiko Yoshioka, Hiroshi Ashida, Minoru Obara, "Transdermal delivery of photosensitizer by laser-induced stress wave", Proc. SPIE 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, (17 June 2002); doi: 10.1117/12.432076; https://doi.org/10.1117/12.432076
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