13 June 2002 Depth-resolved birefringence imaging of the primate retinal nerve fiber layer using polarization-sensitive OCT
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Proceedings Volume 4611, Ophthalmic Technologies XII; (2002); doi: 10.1117/12.470599
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States
Abstract
Imaging the optical phase retardation per unit depth (OPR/UD) in the retinal nerve fiber layer (RNFL) may aid in glaucoma diagnosis. Polarization Sensitive Optical Coherence Tomography (PSOCT) was used to record in vivo high-resolution images of the RNFL in two cynomologous monkeys. The depth variation in the Stokes vector of reflected light was used to calculate the OPR/UD as a function of RNFL position. OPR/UD decreased from 35 degree(s)/100 micrometers near the optic nerve to 5 degree(s)/100 micrometers at a location 600 micrometers superior to the optic nerve. Variation of OPR/UD in the RNFL with retinal position demonstrates a change in birefringence for different densities of ganglion cell axons. PSOCT may be useful for noninvasive determination of RNFL thickness and fiber density.
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Nathaniel Joseph Kemp, Jesung Park, Jason D. Marsack, Digant P. Dave, Sapun H. Parekh, Thomas E. Milner, Henry Grady Rylander, "Depth-resolved birefringence imaging of the primate retinal nerve fiber layer using polarization-sensitive OCT", Proc. SPIE 4611, Ophthalmic Technologies XII, (13 June 2002); doi: 10.1117/12.470599; https://doi.org/10.1117/12.470599
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KEYWORDS
Birefringence

Polarization

Optical coherence tomography

Nerve

Optic nerve

Eye

Mirrors

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