Treatment planning platform for photodynamic therapy: architecture, function, and validation

Brian C. Wilson; William Mark Whelan; Sean R. H. Davidson; Robert A. Weersink; Michael D. Sherar

doi:10.1117/12.469335

6 June 2002 Treatment planning platform for photodynamic therapy: architecture, function, and validation

Brian C. Wilson, William Mark Whelan, Sean R. H. Davidson, Robert A. Weersink, Michael D. Sherar

Proceedings Volume 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI; (2002) https://doi.org/10.1117/12.469335
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

The construction of a software platform for planning of photodynamic therapy (PDT) treatments is described. Its use is illustrated by the planning of a treatment of prostate cancer using multiple interstitial optical fiber sources. The effects of changing tissue optical properties, of photosensitizer photobleaching and of altering the power distribution between the sources are demonstrated. Validation tests of the PDT dose calculation algorithms and the software implementation of these are included. The possibility of compensating for misplaced sources is shown and confirmed experimentally in a tissue-simulating phantom. The future development of this platform and its integration into a complete solution planning-delivery-control platform is discussed.

Citation Download Citation

Brian C. Wilson, William Mark Whelan, Sean R. H. Davidson, Robert A. Weersink, and Michael D. Sherar "Treatment planning platform for photodynamic therapy: architecture, function, and validation", Proc. SPIE 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI, (6 June 2002); https://doi.org/10.1117/12.469335

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