1 May 2002 Compact fluorescence spectroscopic tool for cancer detection
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Proceedings Volume 4613, Optical Biopsy IV; (2002); doi: 10.1117/12.465261
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States
Abstract
We describe a compact fluorescence spectroscopic tool for in vivo point monitoring of aminolaevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence and autofluorescence, as a non-invasive method of differentiating normal and cancerous tissue. This instrument incorporates a 405nm diode laser with a shutter to prevent exposure of tissue to harmful light doses and reduce photobleaching, a bifurcated optical fibre to allow illumination of tissue and collection of fluorescence with a single fibre, a compact grating spectrometer for collection of spectra and a PC for system control. We present spectra obtained using this system both during routine gastro-intestinal (GI) endoscopy for cancer detection and during photodynamic therapy (PDT) of anal intraepithelial neoplasia (AIN) for monitoring of treatment progress. These results illustrate the potential of the system to be used for fluorescence monitoring in a variety of clinical applications.
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Valerie Nadeau, Khaled Hamdan, Jacqueline Hewett, Juljia Makaryceva, Iain Tait, Alfred Cuschieri, Miles J. Padgett, "Compact fluorescence spectroscopic tool for cancer detection", Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); doi: 10.1117/12.465261; https://doi.org/10.1117/12.465261
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KEYWORDS
Luminescence

Tissue optics

Photodynamic therapy

Spectroscopy

Cancer

Fluorescence spectroscopy

Tissues

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