Detection of experimental brain tumors using time-resolved laser-induced fluorescence spectroscopy

Reid C. Thompson; Keith L. Black; Babak Kateb; Laura Marcu

doi:10.1117/12.465236

1 May 2002 Detection of experimental brain tumors using time-resolved laser-induced fluorescence spectroscopy

Reid C. Thompson, Keith L. Black, Babak Kateb, Laura Marcu

Proceedings Volume 4613, Optical Biopsy IV; (2002) https://doi.org/10.1117/12.465236
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Time-Resolved Laser-Induced Fluorescence Spectroscopy (TR-LIFS) has the potential to provide a non- invasive characterization and detection of tumors. We utilized TR-LIFS to detect gliomas in-vivo in the rat C6 glioma model. Time-resolved emission spectra of both normal brain and tumor were analyzed to determine if unique fluorescence signatures could be used to distinguish the two. Fluorescence parameters derived from both spectral and time domain were used for tissue characterization. Our results show that in the rat C6 glioma model, TR-LIFS can be used to differentiate brain tumors from normal tissue (gray and white mater) based upon time- resolved fluorescence signatures seen in brain tumors.

Citation Download Citation

Reid C. Thompson, Keith L. Black, Babak Kateb, and Laura Marcu "Detection of experimental brain tumors using time-resolved laser-induced fluorescence spectroscopy", Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); https://doi.org/10.1117/12.465236

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