27 March 2002 Infrared fiber optic evanescent wave spectroscopy for the study of diffusion in the human skin
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Proceedings Volume 4614, Biomedical Vibrational Spectroscopy II; (2002) https://doi.org/10.1117/12.460784
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States
Fourier Transform Infrared (FTIR) spectroscopic systems make use of Attenuated Total Reflection (ATR) elements for the study of skin in dermatology. FTIR - ATR allows real time and reagent-less analysis of several components, simultaneously. The potential for skin studies is increased by the development of the flexible fiber optic sensor made from infrared transparent polycrystalline silver halide. Segments of fibers can replace the ATR sensing elements inside an FTIR system. Moreover a Fiberoptic Evanescent Wave Spectroscopy (FEWS) can also be used for real time in vivo measurement on skin, in situ. We used FEWS to study the diffusion of UV sunscreen lotions from the outer skin layer into the dermis and epidermis, and used the various absorption bands to differentiate between the behavior of the organic and the water molecules in the lotion. FEWS can be a powerful tool for studying the transport of drugs and cosmetic creams through the skin from the stratum corneum to the dermis and epidermis and for studying the lateral diffusion of various molecules into the skin, in vivo and in real time.
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Yosef Raichlin, Yosef Raichlin, I. Goldberg, I. Goldberg, Sarah Brenner, Sarah Brenner, Evgeny Shulzinger, Evgeny Shulzinger, Abraham Katzir, Abraham Katzir, } "Infrared fiber optic evanescent wave spectroscopy for the study of diffusion in the human skin", Proc. SPIE 4614, Biomedical Vibrational Spectroscopy II, (27 March 2002); doi: 10.1117/12.460784; https://doi.org/10.1117/12.460784

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