26 March 2002 Probing brain cancer by fiber optic FTIR spectroscopy
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Proceedings Volume 4616, Optical Fibers and Sensors for Medical Applications II; (2002) https://doi.org/10.1117/12.463822
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States
Abstract
The use of several silver halide and chalcogenide infrared transmitting fibers in the detection of cancer is investigated. As a test sample for all types of fibers we used a thin section of an entire rat brain with glioblastoma. Moving the sample with an XY stage maps across the whole tissue section with more than 200 spectra were recorded. Data evaluation was performed using Principal Components Analysis (PCA). The silver halide fibers have provided excellent results. The tumor was clearly differentiable from the normal tissue. It wasn't possible to identify the tumor region using chalcogenide fibers because the fiber has a very low transmittance in the important fingerprint region.
© (2002) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Gerald Steiner, Gerald Steiner, Angelique Kano, Angelique Kano, Tom Richter, Tom Richter, Ralf Bergmann, Ralf Bergmann, Heike Rodig, Heike Rodig, Jens Kobelke, Jens Kobelke, Bernd Johannsen, Bernd Johannsen, Reiner Salzer, Reiner Salzer, } "Probing brain cancer by fiber optic FTIR spectroscopy", Proc. SPIE 4616, Optical Fibers and Sensors for Medical Applications II, (26 March 2002); doi: 10.1117/12.463822; https://doi.org/10.1117/12.463822
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