10 June 2002 Optoacoustic imaging of blood for visualization and diagnostics of breast cancer
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Proceedings Volume 4618, Biomedical Optoacoustics III; (2002); doi: 10.1117/12.469851
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States
Aggressive malignant tumors may be diagnosed based on relative concentration of oxyhemoglobin and deoxyhemoglobin in the tumor microvasculature. Optoacoustic images of breast cancer and prostate cancer may be acquired at two laser wavelengths matching maximum of oxyhemoglobin (1064-nm, Nd:YAG laser) and deoxyhemoglobin (760-nm, Alexandrite laser). Two optoacoustic systems operating in forward and backward mode respectively for breast cancer and prostate cancer detection, employing arrays of ultravide-band piezoelectric transducers and multichannel electronics was described. After systems testing and calibration in phantoms, initial experiments were performed on patients with suspicious tumors. Quantitative analysis of two-color optoacoustic images was correlated with biopsy and histology. Possibility for tumor differentiation was demonstrated.
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Alexander A. Oraevsky, Elena V. Savateeva, Sergey V. Solomatin, Alexander A. Karabutov, Valeri G. Andreev, Zoran Gatalica, Tuenchit Khamapirad, P. Mark Henrichs, "Optoacoustic imaging of blood for visualization and diagnostics of breast cancer", Proc. SPIE 4618, Biomedical Optoacoustics III, (10 June 2002); doi: 10.1117/12.469851; https://doi.org/10.1117/12.469851

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