14 June 2002 Sensitivity estimation of spectroscopic optical coherence tomography
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Proceedings Volume 4619, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI; (2002) https://doi.org/10.1117/12.470475
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States
This study aims to investigate the sensitivity of spectroscopic optical coherence tomography (OCT) to small changes in the absorption properties of the imaged object as well as to evaluate its ability to resolve spatial variations in the object's absorption coefficient. Spectroscopic OCT would have the advantage to provide spatially resolved spectroscopic information at multiple wavelengths across the available bandwidth of the light source in a single measurement. An ultrahigh resolution OCT system based on a Ti:sapphire source emitting in the range of 700 nm to 900 nm with an optical bandwidth of up to 165 nm was used to measure optical absorption of specially designed, non-scattering phantoms. High speed and high resolution digitization in combination with a Morlet wavelet transform was utilized to derive spectroscopic information from the full interference OCT data. Using a non scattering phantom, the preliminary results of the present work reveal the challenges that have to be overcome in order to extract spatially resolved quantitative spectroscopic information by OCT.
© (2002) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Boris Hermann, Boris Hermann, Harald Sattmann, Harald Sattmann, Kostadinka K. Bizheva, Kostadinka K. Bizheva, Boris Povazay, Boris Povazay, Angelika Unterhuber, Angelika Unterhuber, Rainer Leitgeb, Rainer Leitgeb, Leopold F. Schmetterer, Leopold F. Schmetterer, Ferenc Krausz, Ferenc Krausz, Adolf Friedrich Fercher, Adolf Friedrich Fercher, Wolfgang Drexler, Wolfgang Drexler, } "Sensitivity estimation of spectroscopic optical coherence tomography", Proc. SPIE 4619, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI, (14 June 2002); doi: 10.1117/12.470475; https://doi.org/10.1117/12.470475

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